Reaktion #215765

Reaktionsgleichung

2-Methoxy-4-(1-Boc-4-piperidyloxy)benzoic acid

HCl

→

2-methoxy-4-(4-piperidyloxy)benzoic acid

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe mixture was evaporated in vacuo
2. 2
   Einengenthe residue concentrated from ether three times

Vorschrift

2-Methoxy-4-(1-Boc-4-piperidyloxy)benzoic acid (0.79 g, 2.24 mmol) was dissolved in ethyl acetate (15 ml). The solution was cooled in ice and saturated with HCl gas, then stirred 30 min in the cold. The mixture was evaporated in vacuo and the residue concentrated from ether three times to give 2-methoxy-4-(4-piperidyloxy)benzoic acid.

Quelle