Reaktion #215709

Reaktionsgleichung

ethyl 2-(2,5-dichloro-3,4,6-trifluorobenzoyl)-3-cyclopropylamino-acrylate

sodium fluoride

water

→

Ethyl 5,8-dichloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Lösungsmittel

N-methyl-2-pyrrolidone

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling
2. 2
   SonstigeThe solid which has precipitated
3. 3
   Filtrationis filtered off with suction
4. 4
   Waschenwashed with water
5. 5
   Sonstigedried at 80° C. in a drying cabinet

Vorschrift

19.1 g (0.05 mol) of ethyl 2-(2,5-dichloro-3,4,6-trifluorobenzoyl)-3-cyclopropylamino-acrylate are heated at 160°-170° C. together with 4.2 g (0.1 mol) of sodium fluoride in 100 ml of N-methyl-2-pyrrolidone for 5 hours. After cooling, the mixture is poured onto 200 ml of water. The solid which has precipitated is filtered off with suction, washed with water and dried at 80° C. in a drying cabinet.

Quelle