Reaktion #215676

Reaktionsgleichung

4-(benzyloxy)phenol

potassium methoxide

4-(trifluoromethoxy)-2-nitro-1-chlorobenzene

→

4-[4-(trifluoromethoxy)-2-nitrophenoxy]-phenyl benzyl ether

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONTo a mixture of 10.01 g
2. 2
   TemperaturThe mixture is heated
3. 3
   Sonstigethe reaction
4. 4
   SonstigeMost of the solvent is removed at reduced pressure
5. 5
   workup.ADDITIONthe residue treated with methylene chloride and water
6. 6
   WaschenThe methylene chloride solution is washed with saturated brine
7. 7
   Sonstigedried
8. 8
   Sonstigethe solvent removed

Vorschrift

To a mixture of 10.01 g. of 4-(benzyloxy)phenol and 3.51 g. (0.05 mole) of potassium methoxide in 75 ml. of DMF is added 12.08 g. (0.05 mole) of 4-(trifluoromethoxy)-2-nitro-1-chlorobenzene. The mixture is heated to complete the reaction. Most of the solvent is removed at reduced pressure and the residue treated with methylene chloride and water. The methylene chloride solution is washed with saturated brine, dried, and the solvent removed, leaving 4-[4-(trifluoromethoxy)-2-nitrophenoxy]-phenyl benzyl ether.

Quelle