Reaktion #2156152

Reaktionsgleichung

methyl 4-fluoro-2-methoxy-5-nitrobenzoate

2-cyclohexylimidazole

potassium carbonate

N,N-dimethylacetamide

→

title compound

Ausbeute 100.7%

Methyl 4-(2-cyclohexyl-1H-imidazol-1-yl)-2-methoxy-5-nitrobenzoate

Ausbeute 100.7%

Lösungsmittel

water

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction liquid
2. 2
   Sonstigethe organic layer was separated
3. 3
   WaschenThe organic layer was washed with brine
4. 4
   Trocknendried over magnesium sulfate
5. 5
   Sonstigeremoved of the solvent by distillation

Vorschrift

A mixture of methyl 4-fluoro-2-methoxy-5-nitrobenzoate 8.57 g, 2-cyclohexylimidazole 5.61 g, potassium carbonate 10.34 g and N,N-dimethylacetamide 75 mL was heated at 100° C. for 5 hours in nitrogen atmosphere. The reaction liquid was diluted with ethyl acetate, poured in water and the organic layer was separated. The organic layer was washed with brine, dried over magnesium sulfate and removed of the solvent by distillation to provide 13.52 g of the title compound.

Quelle