Reaktion #2155860

Reaktionsgleichung

2-amino-5-bromo benzothiazole

ethylisocyanate

→

desired product

1-(5-bromobenzo[d]thiazol-2-yl)-3-ethylurea

Lösungsmittel

1,4-dioxane

1,4-dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISTILLATIONwas distilled off
2. 2
   Filtrationfollowed by filtration

Vorschrift

To a solution of 2-amino-5-bromo benzothiazole (0.23 g, 1.0 mmol) in 1,4-dioxane (8.0 mL) was added ethylisocyanate (3.96 mL, 5.0 mmol) and the resulting solution was heated to 80° C. for 16 h. After the completion of the reaction (TLC monitoring), 1,4-dioxane was distilled off followed by co-distillation with n-hexane (2 times). The residue was then stirred with water at 90° C. for 2 h followed by filtration to obtain the desired product that was further washed with hot water and then dried. The residue was finally washed with ether to obtain the desired product (0.18 g, 60%).

Quelle