Reaktion #215568

Reaktionsgleichung

2,3-Dicyano-5-chloro-6-ethylpyrazine

di-n-propylamine

Water

→

2,3-dicyano-5-di-n-propylamino-6-ethylpyrazine

Ausbeute 50.0%

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe solution was cooled to 0° to 5° C.
2. 2
   workup.STIRRINGThe mixture was stirred for 30 minutes
3. 3
   SonstigeThe precipitate was separated by filtration
4. 4
   EinengenThe filtrate was concentrated under reduced pressure
5. 5
   Sonstigeto afford a yellow oily product
6. 6
   Sonstigethe precipitated white powder was recrystallized from ethanol

Vorschrift

2,3-Dicyano-5-chloro-6-ethylpyrazine (1.92 g; 0.01 mole) was dissolved in 30 ml of acetone. The solution was cooled to 0° to 5° C., and with stirring, 2.02 g (0.02 mole) of di-n-propylamine was added dropwise. The mixture was stirred for 30 minutes. The precipitate was separated by filtration. The filtrate was concentrated under reduced pressure to afford a yellow oily product. Water (20 ml) was added to the oily product, and the precipitated white powder was recrystallized from ethanol to afford 1.28 g (yield 50%) of 2,3-dicyano-5-di-n-propylamino-6-ethylpyrazine.

Quelle