Reaktion #215472

ord-232e22bddc044364ba88a91e237aaf9a

Reaktionsgleichung

CCOC(=O)CN(C)S(=O)(=O)c1c(C(=O)OC)sc2cc(Cl)ccc12
methyl 6-chloro-3-{[(ethoxycarbonyl-methyl)-methylamino]sulfonyl}-benzo[b]-thiophene-2-carboxylate
→
COC(=O)C1=C(O)c2sc3cc(Cl)ccc3c2S(=O)(=O)N1C
Methyl 7-chloro-4-hydroxy-2-methyl-2H-[1]-benzothieno [2,3-e]-1,2-thiazine-3-carboxylate-1,1-dioxide
Ausbeute 35.0%

Edukte

—
sodium methylene
CCOC(=O)CN(C)S(=O)(=O)c1c(C(=O)OC)sc2cc(Cl)ccc12
methyl 6-chloro-3-{[(ethoxycarbonyl-methyl)-methylamino]sulfonyl}-benzo[b]-thiophene-2-carboxylate

Reagenzien

Keine

Lösungsmittel

CO
methanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Prepared analogous to Example 1(e) from methyl 6-chloro-3-{[(ethoxycarbonyl-methyl)-methylamino]sulfonyl}-benzo[b]-thiophene-2-carboxylate by reaction with sodium methylene in anhydrous methanol with a yield of 35% of theory.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04259336uspto-grants-1981_03