Reaktion #2153975

ord-9df93ac5037e455dbd2f129d5ff13e1a

Reaktionsgleichung

C[C@@H](c1ccccc1)N1CC[C@@H](CN2CCOCC2)[C@H]1C(N)=O
(2S,3S)-3-morpholin-4-ylmethyl-1-((S)-1-phenyl-ethyl)-pyrrolidine-2-carboxylic acid amide
→
NC(=O)[C@H]1NCC[C@H]1CN1CCOCC1
title compound
NC(=O)[C@H]1NCC[C@H]1CN1CCOCC1
(2S,3S)-3-Morpholin-4-ylmethyl-pyrrolidine-2-carboxylic acid amide

Edukte

C[C@@H](c1ccccc1)N1CC[C@@H](CN2CCOCC2)[C@H]1C(N)=O
(2S,3S)-3-morpholin-4-ylmethyl-1-((S)-1-phenyl-ethyl)-pyrrolidine-2-carboxylic acid amide

Reagenzien

[Pd]
Pd on charcoal

Lösungsmittel

O
H2O

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared in analogy to the procedure described in Step 1.8 but (2S,3S)-3-morpholin-4-ylmethyl-1-((S)-1-phenyl-ethyl)-pyrrolidine-2-carboxylic acid amide (Step 7.2) was used instead of (2S,3R)-3-methyl-1-((S)-1-phenyl-ethyl)-pyrrolidine-2-carboxylic acid amide. Moreover, 10% Pd on charcoal, wet with 50% H2O (Aldrich 330108) was used instead of the dry catalyst.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08293753B2uspto-grants-2012_10