Reaktion #2152502

ord-147b44c68be5402ea57571701a05df4c

Reaktionsgleichung

CC1(c2csc(Cn3cc(N)cn3)n2)OCCO1
1-[4-(2-methyl-[1,3]dioxolan-2-yl)-thiazol-2-ylmethyl]-1H-pyrazol-4-ylamine
O=C(O)/C=C/c1ccc(C(F)(F)F)cc1
(E)-3-(4-trifluoromethyl-phenyl)-acrylic acid
→
CC(=O)c1csc(Cn2cc(NC(=O)/C=C/c3ccc(C(F)(F)F)cc3)cn2)n1
(E)-N-[1-(4-Acetyl-thiazol-2-ylmethyl)-1H-pyrazol-4-yl]-3-(4-trifluoromethyl-phenyl)-acrylamide

Edukte

CC1(c2csc(Cn3cc(N)cn3)n2)OCCO1
1-[4-(2-methyl-[1,3]dioxolan-2-yl)-thiazol-2-ylmethyl]-1H-pyrazol-4-ylamine
O=C(O)/C=C/c1ccc(C(F)(F)F)cc1
(E)-3-(4-trifluoromethyl-phenyl)-acrylic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Following general procedure B followed by C starting from 1-[4-(2-methyl-[1,3]dioxolan-2-yl)-thiazol-2-ylmethyl]-1H-pyrazol-4-ylamine and (E)-3-(4-trifluoromethyl-phenyl)-acrylic acid. LC-MS-conditions 02: tR=0.98 min; [M+H]+=421.22.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08288419B2uspto-grants-2012_10