Reaktion #2151759

Reaktionsgleichung

sodium metabisulphite

1H-indazole-3-carboxaldehyde

4,5-dimethyl-1,2-phenylenediamine

→

5,6-dimethyl-2-(1H-indazol-3-yl)-1H-benzimidazole

Ausbeute 25.8%

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture is refluxed for 4 hours
2. 2
   Filtrationfiltered through paper
3. 3
   EinengenThe collected filtrate is concentrated under reduced pressure
4. 4
   SonstigeThe brown lacquer obtained (340 mg)
5. 5
   Sonstigeis purified by preparative LC-MS

Vorschrift

389 mg of sodium metabisulphite are added, at a temperature in the region of 20° C., to a solution of 300 mg of 1H-indazole-3-carboxaldehyde and 279 mg of 4,5-dimethyl-1,2-phenylenediamine in 3 ml of dimethylformamide. The reaction mixture is refluxed for 4 hours and then cooled to a temperature in the region of 20° C. and filtered through paper. The collected filtrate is concentrated under reduced pressure. The brown lacquer obtained (340 mg) is purified by preparative LC-MS. 138.8 mg of 5,6-dimethyl-2-(1H-indazol-3-yl)-1H-benzimidazole are thus obtained in the form of a beige-coloured powder.

Quelle