Reaktion #2150975

Reaktionsgleichung

N-bromosuccinimide

4,6,7-trimethyl-1-benzofuran-3(2H)-one

→

title compound

Ausbeute 80.4%

5-bromo-4,6,7-trimethyl-1-benzofuran-3(2H)-one

Ausbeute 80.4%

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigesynthesized in Reference Example 44
2. 2
   SonstigeAfter that, the solvent was removed under reduced pressure, and water
3. 3
   workup.ADDITIONwas added to the residue
4. 4
   FiltrationThe generated crystals were collected by filtration
5. 5
   Sonstigerecrystallized from ethyl acetate

Vorschrift

N-bromosuccinimide (27.1 g, 152 mmol) was added to a solution of methylene chloride (200 mL) containing 4,6,7-trimethyl-1-benzofuran-3(2H)-one (20.7 g, 117 mmol) synthesized in Reference Example 44, and the mixture was stirred at room temperature for 24 hours. After that, the solvent was removed under reduced pressure, and water was added to the residue. The generated crystals were collected by filtration, and recrystallized from ethyl acetate to give 24.0 g of the title compound (yield: 80%).

Quelle