Reaktion #215068

Reaktionsgleichung

pyruvic acid

trichloroethyl chloroformate

pyridine

→

trichloroethyl pyruvate

Ausbeute 50.0%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenthe mixture is concentrated in vacuum
2. 2
   workup.ADDITIONdiluted with water
3. 3
   Extraktionextracted with ethyl acetate
4. 4
   WaschenThe extract is washed with 5% HCl
5. 5
   Trocknendried over MgSO4
6. 6
   Sonstigeevaporated
7. 7
   workup.DISTILLATIONdistilled in vacuum

Vorschrift

To a solution of 3.3 g (37.5 mmole) of pyruvic acid and 7.9 g (37.5 mmole) of trichloroethyl chloroformate in 20 ml of dry tetrahydrofuran at 0° is added dropwise 0.6 ml of pyridine. After stirring for 2 hours at room temperature, the mixture is concentrated in vacuum, diluted with water and extracted with ethyl acetate. The extract is washed with 5% HCl, dried over MgSO4, evaporated and distilled in vacuum to give 4.0 g (50%) trichloroethyl pyruvate, bp 75°-82° (17 mm).

Quelle