Reaktion #2150

ord-81b4f491699b43439864ee808917472d

Reaktionsgleichung

CP(C)(=O)Cn1c(=O)c2[nH]cnc2n(-c2ccccc2)c1=O
[1-(3-phenylxanthin-1-yl)methyl]dimethylphosphine oxide
CP(C)(=O)Cn1c(=O)c2[nH]cnc2n(-c2ccccc2)c1=O
[1-(3-Phenylxanthin-1-yl)methyl]dimethylphosphine Oxide
ClCC1CC1
chloromethylcyclopropane
O=C([O-])[O-].[K+].[K+]
potassium carbonate
→
CP(C)(=O)Cn1c(=O)c2c(ncn2CC2CC2)n(-c2ccccc2)c1=O
[1-(7-Cyclopropylmethyl-3-phenylxanthin-1-yl)methyl]dimethylphosphine Oxide

Edukte

CP(C)(=O)Cn1c(=O)c2[nH]cnc2n(-c2ccccc2)c1=O
[1-(3-phenylxanthin-1-yl)methyl]dimethylphosphine oxide
CP(C)(=O)Cn1c(=O)c2[nH]cnc2n(-c2ccccc2)c1=O
[1-(3-Phenylxanthin-1-yl)methyl]dimethylphosphine Oxide
ClCC1CC1
chloromethylcyclopropane
O=C([O-])[O-].[K+].[K+]
potassium carbonate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    FiltrationThe solution was filtered
  2. 2
    Einengenconcentrated
  3. 3
    Sonstigethe residue which remained was chromatographed on silica gel (eluent: ethyl acetate/methanol 10:1)

Vorschrift

3.9 g (0.0123 mol) of [1-(3-phenylxanthin-1-yl)methyl]dimethylphosphine oxide (Example 70) were stirred at 70° C. for 6 hours with 1.33 g (0.0147 mol) of chloromethylcyclopropane and 2 g of potassium carbonate. The solution was filtered and concentrated, and the residue which remained was chromatographed on silica gel (eluent: ethyl acetate/methanol 10:1).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05728686uspto-grants-1998_03