Reaktion #214911

Reaktionsgleichung

diglycolic anhydride

methanesulfonate

5-aminopentanol

→

2-(5-hydroxypentyl)amino-2-oxoethoxylacetic acid

Reaktionsbedingungen

Vorschrift

methanesulfonate by the following sequence of steps: (a) by reacting diglycolic anhydride and 5-aminopentanol to produce [2-(5-hydroxypentyl)amino-2-oxoethoxylacetic acid, (b) heating to cyclize the latter to obtain 4-(5-hydroxypentyl)-3,5-dioxomorpholine, (c) esterifying the latter with methanesulfonyl chloride to produce 5-(3,5-dioxomorpholino)pentyl methanesulfonate and (d) reacting the mesylate with 2-benzhydrylpiperidine.

Quelle