Reaktion #2148175

Reaktionsgleichung

NaOtBu

di-tert-butyl 12-bromo-2,10-difluoro-6-methoxyindolo[2,3-b]carbazole-5,7-dicarboxylate

MeNH2

BINAP

→

title compound

2,10-difluoro-6-methoxy-N-methyl-5,7-dihydroindolo[2,3-b]carbazol-12-amine

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThis compound was obtained
2. 2
   Sonstigeat 80° C.
3. 3
   Sonstigeovernight

Vorschrift

The title compound was prepared in a manner analogous to Example 133. This compound was obtained by heating di-tert-butyl 12-bromo-2,10-difluoro-6-methoxyindolo[2,3-b]carbazole-5,7-dicarboxylate and MeNH2 in a bomb, in the presence of Pd(OAc)2, BINAP, and NaOtBu at 80° C. overnight. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.17 (s, 2H), 8.06 (dd, J=10.2, 2.6 Hz, 2H), 7.39 (dd, J=8.8, 4.4 Hz, 2H), 7.14 (td, J=9.2, 2.4 Hz, 2H), 4.77 (q, J=5.6 Hz, 1H), 4.00 (s, 3H), 3.01 (d, J=5.6 Hz, 3H).

Quelle