Reaktion #214770

Reaktionsgleichung

1-methyl-β-oxo-α-ethoxycarbonyl-2-pyrrolpropionitrile

p-aminophenol

→

1-methyl-β-oxo-α-(p-hydroxyphenylcarbamoyl)-2-pyrrolpropionitrile

Lösungsmittel

xylene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturis refluxed for 2 hours
2. 2
   Filtrationfiltered hot
3. 3
   TemperaturThe filtrate is chilled
4. 4
   Sonstigethe crystals formed
5. 5
   Sonstigecollected
6. 6
   Sonstigerecrystallized from methanol

Vorschrift

The mixture of 5.7 g of 1-methyl-β-oxo-α-ethoxycarbonyl-2-pyrrolpropionitrile, 3,6 g of p-aminophenol and 300 ml of xylene is refluxed for 2 hours and filtered hot. The filtrate is chilled, the crystals formed collected and recrystallized from methanol, to yield the 1-methyl-β-oxo-α-(p-hydroxyphenylcarbamoyl)-2-pyrrolpropionitrile melting at 182°-184°.

Quelle