Reaktion #2146688

Reaktionsgleichung

sodium methoxide methanol

2-bromo-3-hydroxypyridine

methyl iodide

→

2-bromo-3-methoxypyridine

Lösungsmittel

dimethylsulfoxide

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISTILLATIONto distill off methanol
2. 2
   TemperaturAfter the reaction solution was cooled down to 5° C.
3. 3
   SonstigeAfter the completion of the reaction
4. 4
   Extraktionextracted twice with chloroform
5. 5
   WaschenThe combined chloroform layer was washed with a 1 mol/L sodium hydroxide solution
6. 6
   Waschenwashed twice with a saturated sodium chloride solution
7. 7
   Trocknendried over anhydrous sodium sulfate
8. 8
   workup.DISTILLATIONAfter the solvent was distilled off under reduced pressure

Vorschrift

31.11 g (corresponding to 178.88 mmol) of 2-bromo-3-hydroxypyridine was dissolved in 95.8 mL of dimethylsulfoxide, and 89.9 mL (corresponding to 89.9 mmol) of a 1 mol/L sodium methoxide-methanol solution was added thereto. Then, the reaction solution was heated to 90° C. to distill off methanol. After the reaction solution was cooled down to 5° C. or lower, 29.2 g (corresponding to 205.62 mmol) of methyl iodide was added, and then stirred at room temperature for 17 hours. After the completion of the reaction, the reaction solution was poured into ice-water and extracted twice with chloroform. The combined chloroform layer was washed with a 1 mol/L sodium hydroxide solution, washed twice with a saturated sodium chloride solution, and dried over anhydrous sodium sulfate. After the solvent was distilled off under reduced pressure, 20.74 g (corresponding to 110.31 mmol) of 2-bromo-3-methoxypyridine was obtained (FIG. 3, Step 1).

Quelle