Reaktion #214604

Reaktionsgleichung

7-chloro-1,4-benzodioxane-5-carbonyl chloride

N-(aminoethyl)-piperidine

→

N-[piperidino ethyl]-7-chloro-1,4-benzodioxane-5-carboxamide hydrochloride

Ausbeute 129.0%

Lösungsmittel

methyl ethyl ketone

methyl ethyl ketone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeprovided with an agitator
2. 2
   TemperaturThe mixture was cooled
3. 3
   workup.ADDITIONwas added at a temperature of from 15°-20° C
4. 4
   SonstigeAfter agitation the crystals formed
5. 5
   Sonstigewere dried off
6. 6
   Waschenwashed with methyl ethyl ketone

Vorschrift

150 ml of methyl ethyl ketone and 22 g of N-(aminoethyl)-piperidine was introduced into a 500 ml balloon flask provided with an agitator and a thermometer. The mixture was cooled and then a suspension of 35 g of 7-chloro-1,4-benzodioxane-5-carbonyl chloride in 200 ml of methyl ethyl ketone was added at a temperature of from 15°-20° C. After agitation the crystals formed were dried off and then washed with methyl ethyl ketone. 35 g of N-[piperidino ethyl]-7-chloro-1,4-benzodioxane-5-carboxamide hydrochloride was produced (M.P.: 192° C.; yield: 64.5%).

Quelle