Reaktion #214548

Reaktionsgleichung

aluminium chloride

2,3-dichloro-anisol

2-benzofurancarboxylic acid chloride

hydrochloric acid

→

2-benzofuryl (2,3-dichloro-4-methoxy-phenyl) ketone

Ausbeute 76.1%

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto reflux for 4 hours
2. 2
   workup.ADDITIONpoured
3. 3
   Filtrationthe precipitate is filtered off
4. 4
   Waschenwashed with an aqueous solution of sodium hydroxide (10 N)
5. 5
   Trocknenwith water and dried

Vorschrift

14 g (0.1 mole) of aluminium chloride are introduced little by little in a solution of 16 g (0.09 mole) of 2,3-dichloro-anisol and 16 g (0.09 mole) of 2-benzofurancarboxylic acid chloride in 200 ml of methylene chloride the mixture is taken up to reflux for 4 hours, then poured on crushed ice (300 g) and concentrated hydrochloric acid (10 ml); the precipitate is filtered off, washed with an aqueous solution of sodium hydroxide (10 N), then with water and dried. 22 g of 2-benzofuryl (2,3-dichloro-4-methoxy-phenyl) ketone are obtained. Melting point 148° C. after crystallization from ethylacetate.

Quelle