Reaktion #214471

Reaktionsgleichung

8-(3-piperidinyl)-8-azaspiro [4,5]decan-7,9 -dione

4-amino-2-chloro-6,7-dimethoxyquinazoline

→

8-[1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-3-piperidinyl]-8-azaspiro[4,5]decan-7,9-dione hydrochloride

Lösungsmittel

isoamyl alcohol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturrefluxed under nitrogen for 24 hours
2. 2
   TemperaturIt is cooled to 20°
3. 3
   Filtrationthe solids filtered off
4. 4
   Waschenwashed with isoamyl alcohol and diethyl ether
5. 5
   Sonstigerecrystallized from the mixture of 160 ml of methanol and 110 ml of water

Vorschrift

The mixture of 3.75 g of 8-(3-piperidinyl)-8-azaspiro [4,5]decan-7,9 -dione, 3.59 g of 4-amino-2-chloro-6,7-dimethoxyquinazoline and 100 ml of isoamyl alcohol is stirred and refluxed under nitrogen for 24 hours. It is cooled to 20°, the solids filtered off, washed with isoamyl alcohol and diethyl ether and recrystallized from the mixture of 160 ml of methanol and 110 ml of water, to yield the 8-[1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-3-piperidinyl]-8-azaspiro[4,5]decan-7,9-dione hydrochloride melting at 311°-312° with decomposition.

Quelle