Reaktion #2144406

ord-f4898dbbecdd42239493a5e15dc1940e

Reaktionsgleichung

CN[C@H]1CC[C@H](O)CC1
trans-4-Methylamino-cyclohexanol
O=S(=O)(Cl)c1ccc(Br)cc1
4-bromobenzenesulfonylchloride
→
CN([C@H]1CC[C@H](O)CC1)S(=O)(=O)c1ccc(Br)cc1
trans-4-Bromo-N-(4-hydroxy-cyclohexyl)-N-methyl-benzenesulfonamide

Edukte

CN[C@H]1CC[C@H](O)CC1
trans-4-Methylamino-cyclohexanol
O=S(=O)(Cl)c1ccc(Br)cc1
4-bromobenzenesulfonylchloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In analogy to example 11.9D. trans-4-Methylamino-cyclohexanol and 4-bromobenzenesulfonylchloride were reacted to yield trans-4-Bromo-N-(4-hydroxy-cyclohexyl)-N-methyl-benzenesulfonamide as off-white solid, MS: 348 (MH+, 1Br).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07335687B2uspto-grants-2008_02