Reaktion #214421

Reaktionsgleichung

1-bromo-4-chloro-3,3-dimethyl-butan-2-one

4-(4-chlorophenyl)-phenol

potassium carbonate

→

4-chloro-1-[4-(4-chlorophenyl)-phenoxy]-3,3-dimethyl-butan-2-one

Ausbeute 55.6%

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturunder reflux
2. 2
   Temperaturto cool
3. 3
   Filtrationthe inorganic residue was filtered off
4. 4
   Waschenrinsed with acetone
5. 5
   EinengenThe filtrate was concentrated
6. 6
   workup.DISTILLATIONby distilling off the solvent in vacuo
7. 7
   SonstigeThe residue crystallized
8. 8
   workup.ADDITIONafter the addition of 50 ml of diisopropyl ether

Vorschrift

42.7 g (0.2 mol) of 1-bromo-4-chloro-3,3-dimethyl-butan-2-one were added dropwise to a boiling suspension of 41 g (0.2 mol) of 4-(4-chlorophenyl)-phenol and 28 g (0.2 mol) of potassium carbonate in 300 ml of absolute acetone. The mixture was stirred for 15 hours under reflux and was then allowed to cool and the inorganic residue was filtered off and rinsed with acetone. The filtrate was concentrated by distilling off the solvent in vacuo. The residue crystallized after the addition of 50 ml of diisopropyl ether. 37.5 g (55% of theory) of 4-chloro-1-[4-(4-chlorophenyl)-phenoxy]-3,3-dimethyl-butan-2-one of melting point 67°-68° C. were obtained.

Quelle