Reaktion #214389

Reaktionsgleichung

2-[2-(5-methyl-4-imidazolylmethylthio) ethylamino]-5-(4-methoxy-2-pyridylmethyl)-4-pyrimidone

hydrobromic acid

→

5-(4-hydroxy-2-pyridylmethyl)-4-pyrimidone trihydrobromide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturunder reflux for 20 hours
2. 2
   Sonstigeevaporated to dryness
3. 3
   SonstigeThe residue was recrystallised from a mixture of ethanol and 2-propanol

Vorschrift

A mixture of 2-[2-(5-methyl-4-imidazolylmethylthio) ethylamino]-5-(4-methoxy-2-pyridylmethyl)-4-pyrimidone (0.97 g) and aqueous hydrobromic acid (48%, 20 ml) was boiled under reflux for 20 hours and evaporated to dryness. The residue was recrystallised from a mixture of ethanol and 2-propanol to give 2-]2-(5-methyl-4-imidazolylmethylthio) ethylamino]-5-(4-hydroxy-2-pyridylmethyl)-4-pyrimidone trihydrobromide, m.p. 167-169°. On recrystallisation from a mixture of ethanol and 2-propanol the melting point of the sample was lower owing to loss of hydrogen bromide.

Quelle