Reaktion #214388

ord-06d75e9eee97420e980a2f62bef5b330

Reaktionsgleichung

COc1ccnc(Cc2cnc(N[N+](=O)[O-])[nH]c2=O)c1
2-nitroamino-5-(4-methoxy-2-pyridylmethyl)-4-pyrimidone
Cc1[nH]cnc1CSCCN
2-(5-methyl-4-imidazolylmethylthio)ethylamine
CCO
ethanol
→
COc1ccnc(Cc2cnc(NCCSCc3nc[nH]c3C)[nH]c2=O)c1
2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(4-methoxy-2-pyridylmethyl)-4-pyrimidone

Edukte

COc1ccnc(Cc2cnc(N[N+](=O)[O-])[nH]c2=O)c1
2-nitroamino-5-(4-methoxy-2-pyridylmethyl)-4-pyrimidone
Cc1[nH]cnc1CSCCN
2-(5-methyl-4-imidazolylmethylthio)ethylamine
CCO
ethanol

Reagenzien

Keine

Lösungsmittel

CC(C)O
2-propanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Reaction of 2-nitroamino-5-(4-methoxy-2-pyridylmethyl)-4-pyrimidone with 1.06 molar equivalents of 2-(5-methyl-4-imidazolylmethylthio)ethylamine in refluxing ethanol for 24 hours gave 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(4-methoxy-2-pyridylmethyl)-4-pyrimidone, m.p. 128-130° (from 2-propanol).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04255428uspto-grants-1981_03