Reaktion #214379

Reaktionsgleichung

2-nitroamino-5-(6-methoxy-3-pyridylmethyl)-4-pyrimidone

2-(5-methyl-4-imidazolyl methylthio)-ethylamine

→

2-[2-(5-methyl-4-imidazolyl methylthio)ethylamino]-5-(6-methoxy-3-pyridylmethyl)-4-pyrimidone

Ausbeute 63.0%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solid which crystallised out
2. 2
   Temperaturon cooling
3. 3
   Sonstigewas recrystallised from ethanol

Vorschrift

An equimolar mixture of 2-nitroamino-5-(6-methoxy-3-pyridylmethyl)-4-pyrimidone and 2-(5-methyl-4-imidazolyl methylthio)-ethylamine was refluxed in ethanol for 18 hours. The solid which crystallised out on cooling was recrystallised from ethanol to give 2-[2-(5-methyl-4-imidazolyl methylthio)ethylamino]-5-(6-methoxy-3-pyridylmethyl)-4-pyrimidone, m.p. 197-198.5° in 63% yield.

Quelle