Reaktion #214315

Reaktionsgleichung

2-Bromo-1,1-dimethoxyethane

1,3-butanediol

Toluene sulfonic acid

→

2-bromomethyl-4-methyl-1,3-dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigefitted with a mechanical stirrer
2. 2
   Temperaturthermometer, Dean Stark trap and reflux condenser
3. 3
   Temperaturthe reaction mixture is heated
4. 4
   Sonstigealcohol removed
5. 5
   workup.ADDITIONtreated with sodium carbonate (5 grams)
6. 6
   Filtrationfiltered
7. 7
   Sonstigea rotary evaporator

Vorschrift

2-Bromo-1,1-dimethoxyethane (0.1 mole) and 1,3-butanediol (0.1 mole) are charged into a glass reaction vessel fitted with a mechanical stirrer, thermometer, Dean Stark trap and reflux condenser. Toluene sulfonic acid (0.1 grams) is added and the reaction mixture is heated and alcohol removed. When alcohol evolution ceases, the reaction mixture is then cooled to room temperature, treated with sodium carbonate (5 grams) and filtered. Volatiles are stripped from the filtrate using a rotary evaporator to yield the desired product 2-bromomethyl-4-methyl-1,3-dioxane as the residue.

Quelle