Reaktion #214221

Reaktionsgleichung

methyl 4-trichloromethyl-6,6-dimethyl-2-oxo-3-oxabicyclo[3.1.0]hexane-1-carboxylate

lithium chloride

→

4-trichloromethyl-6,6-dimethyl-2-oxo-3-oxabicyclo[3.1.0]hexane

Ausbeute 28.0%

Lösungsmittel

ether

hexamethylphosphoric triamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter heating at 75° for two hours
2. 2
   Sonstigethe cooled reaction mixture
3. 3
   WaschenThe ethereal solution was washed with water
4. 4
   Trocknendried over magnesium sulfate
5. 5
   Sonstigethe ether was removed by evaporation
6. 6
   Sonstigeyielding a residue which
7. 7
   Sonstigewas purified by column chromatography on silica gel using 9/1 n-hexane/ethylacetate as the eluent

Vorschrift

To a solution of methyl 4-trichloromethyl-6,6-dimethyl-2-oxo-3-oxabicyclo[3.1.0]hexane-1-carboxylate (1.52 g, 0.005 mole) in 10 ml of hexamethylphosphoric triamide was added lithium chloride (0.42 g, 0.010 mole). After heating at 75° for two hours, the cooled reaction mixture was diluted with ether. The ethereal solution was washed with water, dried over magnesium sulfate, and the ether was removed by evaporation, yielding a residue which was purified by column chromatography on silica gel using 9/1 n-hexane/ethylacetate as the eluent to give 4-trichloromethyl-6,6-dimethyl-2-oxo-3-oxabicyclo[3.1.0]hexane (0.34 g, 28% yield) as an oil.

Quelle