Reaktion #2139917

Reaktionsgleichung

4-methyl-3-thiosemicarbazide

acetone

chloroacetone

→

3,4-Dimethyl-2(3H)-thiazolone-(1-methylethyliden) hydrazone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux for 2 hours
2. 2
   TemperaturThe reaction mixture was heated
3. 3
   Temperaturat reflux for 7 hours
4. 4
   Einengenconcentrated
5. 5
   SonstigeThe resulting crude product was recrystallized from acetone

Vorschrift

21 g (200 mmol) of 4-methyl-3-thiosemicarbazide in 1000 mL of acetone was heated at reflux for 2 hours. To the solution was then added dropwise 20.4 g (220 mmol) of chloroacetone. The reaction mixture was heated at reflux for 7 hours and concentrated. The resulting crude product was recrystallized from acetone. This gave 23 g of an orange powder (63% of the theoretical).

Quelle