Reaktion #2139906

ord-efbca071b4d343cf9aff19e00611d2dd

Reaktionsgleichung

O.O=C(O)c1cc(=O)[nH]c(=O)[nH]1
orotic acid monohydrate
O.O=C(O)c1[nH]c(=O)[nH]c(=O)c1F
5-fluoro-orotic acid monohydrate
→
O=c1[nH]cc(F)c(=O)[nH]1
5-fluorouracil

Edukte

O.O=C(O)c1cc(=O)[nH]c(=O)[nH]1
orotic acid monohydrate
O.O=C(O)c1[nH]c(=O)[nH]c(=O)c1F
5-fluoro-orotic acid monohydrate

Reagenzien

Keine

Reaktionsbedingungen

Temperatur
260°CELSIUS
Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeIn the reaction

Vorschrift

In the reaction, the conversion of the orotic acid monohydrate was 100% and the yield of 5-fluoro-orotic acid monohydrate was 85.0%. The crystals were heated at 260° C. under a reduced pressure of lower than 1 mmHg to perform the decarboxylation to obtain 22.5 g of 5-fluorouracil.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04186266uspto-grants-1980_01