Reaktion #2139873

Reaktionsgleichung

sodium methoxide

1-(2-amino-phenyl)-5-chloroindoline hydrochloride

dimethylformamide

dimethylamine

→

5-Chloro-1-(2-formamidophenyl)indoline

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeis immersed in a 100° C.
2. 2
   Temperaturpre-heated oil bath
3. 3
   Sonstigeoccurs at 60° C.
4. 4
   workup.ADDITIONis added in one portion
5. 5
   TemperaturThe mixture is rapidly heated
6. 6
   Temperaturto reflux
7. 7
   Sonstigeto precipitate the product as an oil
8. 8
   SonstigeThe water is removed by decantation
9. 9
   Extraktionextracted with H2O, with 3N
10. 10
    TrocknenHCl, once again with H2O, dried over sodium sulfate
11. 11
    Einengenconcentrated to a hard glass
12. 12
    workup.DISSOLUTIONThis is dissolved in hot benzene (charcoal) to which hexane
13. 13
    workup.ADDITIONis added
14. 14
    SonstigeThe solid of 5-chloro-1-(2-formamidophenyl)indoline, m.p. 126°-129° C. is collected

Vorschrift

A stirred mixture, under N2, of 24.3 g of 1-(2-amino-phenyl)-5-chloroindoline hydrochloride, of Example 5, and 150 ml of dry dimethylformamide (DMF) is immersed in a 100° C. pre-heated oil bath. Solution occurs at 60° C. when 14.4 g of solid sodium methoxide is added in one portion. The mixture is rapidly heated to reflux and kept there for 45 minutes during which dimethylamine evolves copiously. The reaction mixture is then treated, in portions and without further heating, with 2 liters of water to precipitate the product as an oil. The water is removed by decantation. The oil is taken up in chloroform, extracted with H2O, with 3N--HCl, once again with H2O, dried over sodium sulfate and concentrated to a hard glass. This is dissolved in hot benzene (charcoal) to which hexane is added. The solid of 5-chloro-1-(2-formamidophenyl)indoline, m.p. 126°-129° C. is collected.

Quelle