Reaktion #2139872

Reaktionsgleichung

5-chloro-1-(2-nitrophenyl)indoline

HCl

→

1-(2-Aminophenyl)-5-chloroindoline hydrochloride

Lösungsmittel

ethanol

ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe mixture is filtered
2. 2
   Sonstigethe solvent removed at 50° C.
3. 3
   Sonstigeto leave the product base as an oil
4. 4
   Sonstigeto precipitate 1-(2-aminophenyl)-5-chloroindoline hydrochloride, m.p. 235°-238° C. dec.

Vorschrift

A mixture of 13.7 g of 5-chloro-1-(2-nitrophenyl)indoline and 0.25 g of 1% Pt on C in 250 ml absolute ethanol is shaken at 50 psi of H2 until the theoretical amount of H2 is taken up. The mixture is filtered and the solvent removed at 50° C. to leave the product base as an oil. This is dissolved in 200 ml of ether, cooled to 0° C., and treated with gaseous HCl to precipitate 1-(2-aminophenyl)-5-chloroindoline hydrochloride, m.p. 235°-238° C. dec.

Quelle