Reaktion #2139246

Reaktionsgleichung

2-Amino-1-methylimidazoline hydroiodide

sodium hydroxide

phenylisothiocyanate

→

N-(1-methyl-2-imidazolidinylidene)-N'-phenylthiourea

Ausbeute 86.1%

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionThe base is extracted with methylene chloride
2. 2
   Trocknenthe extract dried over potassium carbonate
3. 3
   Filtrationfiltered
4. 4
   Temperaturthe reaction mixture is refluxed for three hours
5. 5
   FiltrationThe hot solution is filtered
6. 6
   Einengenconcentrated to a small volume in vacuo, ether
7. 7
   workup.ADDITIONadded
8. 8
   Temperaturchilled
9. 9
   Filtrationthe solid filtered off

Vorschrift

2-Amino-1-methylimidazoline hydroiodide (26.75 g, 0.117 mole) is converted to its free base form by treatment with 50% sodium hydroxide. The base is extracted with methylene chloride and the extract dried over potassium carbonate and filtered. To this solution is added phenylisothiocyanate (15.81 g, 0.117 mole) and the reaction mixture is refluxed for three hours. The hot solution is filtered, concentrated to a small volume in vacuo, ether added, chilled, and the solid filtered off to give 23.6 g (86.1%) of N-(1-methyl-2-imidazolidinylidene)-N'-phenylthiourea; m.p. 205°-208° C.

Quelle