Reaktion #2139

Reaktionsgleichung

theophylline sodium salt

chloromethyldimethyl-phosphine oxide

DMF

→

[1-(3,7-Dimethylxanthin-1-yl)methyl]dimethylphosphine Oxide

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe solution was filtered
2. 2
   Sonstigethe solvent was evaporated
3. 3
   FiltrationThe precipitate was filtered off
4. 4
   Sonstigedried to constant weight under reduced pressure

Vorschrift

A solution of 20.2 g (0.1 mol) of theophylline sodium salt in 400 ml of DMF was heated at 130° C. for 3 hours with 12.7 g of chloromethyldimethyl-phosphine oxide. The solution was filtered, the solvent was evaporated and the residue was taken up in methanol. The precipitate was filtered off and dried to constant weight under reduced pressure.

Quelle