Reaktion #2128987

Reaktionsgleichung

polysiloxane

Gelva

ethyl acetate

isopropyl alcohol

dipropylene glycol

oleic acid

→

estradiol norethindrone acetate

Lösungsmittel

toluene

ethanol

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONthoroughly mixed in an appropriate container until the mixture
2. 2
   Einengenthe ingredient concentrations on a dry weight percent basis (i.e.
3. 3
   Sonstigeafter evaporation of the volatile solvents)

Vorschrift

An estradiol/norethindrone acetate pressure-sensitive adhesive mixture was prepared by combining 5.68 grams of a polyoxazoline polymer [Aquazol® 50] with 5.68 grams of isopropyl alcohol and 5.71 grams of toluene. Then 66.41 grams of a polysiloxane adhesive (BIO-PSA®-4603, trimethylated silica treatment with dimethyl siloxane in toluene; Dow Corning Corporation, Medical Products, Midland, Mich.), 8.74 grams of a polyacrylate adhesive (Gelva® 737, an acrylic resin in ethyl acetate, ethanol and toluene; Surface Specialties, Springfield, Mass.), 2.27 grams of dipropylene glycol and 3.41 grams of oleic acid were added as co-solvents and enhancers, and thoroughly mixed in an appropriate container until the mixture was completely homogeneous. The resulting composition had the ingredient concentrations on a dry weight percent basis (i.e., after evaporation of the volatile solvents) as shown below.

Quelle