Reaktion #2127

ord-6f7760bc41454f178cfc2b916e1815a1

Reaktionsgleichung

CCOP(=O)(CCCCn1c(=O)c2[nH]cnc2n(CC)c1=O)OCC
diethyl [4-(3-ethyl-xanthin-1-yl)butyl]phosphonate
CCCBr
bromopropane
→
CCCn1cnc2c1c(=O)n(CCCCP(=O)(OCC)OCC)c(=O)n2CC
Diethyl [4-(3-ethyl-7-propylxanthin-1-yl)butyl]phosphonate

Edukte

CCOP(=O)(CCCCn1c(=O)c2[nH]cnc2n(CC)c1=O)OCC
diethyl [4-(3-ethyl-xanthin-1-yl)butyl]phosphonate
CCCBr
bromopropane

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigechromatographed on silica gel (eluent: dichloromethane/methanol 20:1)

Vorschrift

The title substance was prepared from 8.2 mmol of diethyl [4-(3-ethyl-xanthin-1-yl)butyl]phosphonate and 9.8 mmol of bromopropane analogously to Example 30 and chromatographed on silica gel (eluent: dichloromethane/methanol 20:1).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05728686uspto-grants-1998_03