Reaktion #2126831

Reaktionsgleichung

methyl 6-chloronicotinate

N-benzylethylenediamine

water

→

crude product

6-(2-Benzylaminoethylamino)nicotinic acid methyl ester

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe resulting product is dried
2. 2
   Sonstigeevaporated under vacuum

Vorschrift

4.6 g of methyl 6-chloronicotinate and 40.5 ml of N-benzylethylenediamine are heated at 135° C. for 6 hours in a round-bottomed flask. The resulting product is poured into water and extraction is carried out with ethyl acetate. The resulting product is dried and evaporated under vacuum; the crude product thus obtained is purified by flash chromatography.

Quelle