Reaktion #2123279

ord-21db5bbe6f67459692392a7159629800

Reaktionsgleichung

[Li+].[O-][Cl+3]([O-])([O-])[O-]
lithium perchlorate
O=C(OCc1ccccc1)N1CCC2(CC1)CO2
benzyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate
Nc1ccc(F)cc1
4-fluoroaniline
→
O=C(OCc1ccccc1)N1CCC(O)(CNc2ccc(F)cc2)CC1
benzyl 4-{[(4-fluorophenyl)amino]methyl}-4-hydroxypiperidine-1-carboxylate

Edukte

[Li+].[O-][Cl+3]([O-])([O-])[O-]
lithium perchlorate
—
product
O=C(OCc1ccccc1)N1CCC2(CC1)CO2
benzyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate
Nc1ccc(F)cc1
4-fluoroaniline

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The object product (2.8 g, 98%) was obtained in the same manner as in Example 24(1) and using benzyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate (1.98 g), 4-fluoroaniline (889 mg) and lithium perchlorate (960 mg).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08575167B2uspto-grants-2013_11