Reaktion #2123275

ord-86f0d69ce3094d098ece31f3c333a679

Reaktionsgleichung

[Li+].[O-][Cl+3]([O-])([O-])[O-]
lithium perchlorate
O=C(OCc1ccccc1)N1CCC2(CC1)CO2
benzyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate
NCC1CC1
1-cyclopropylmethanamine
→
O=C(OCc1ccccc1)N1CCC(O)(CNCC2CC2)CC1
benzyl 4-{[(cyclopropylmethyl)amino]methyl}-4-hydroxypiperidine-1-carboxylate

Edukte

[Li+].[O-][Cl+3]([O-])([O-])[O-]
lithium perchlorate
—
product
O=C(OCc1ccccc1)N1CCC2(CC1)CO2
benzyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate
NCC1CC1
1-cyclopropylmethanamine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The object product (2.53 g, 99%) was obtained in the same manner as in Example 24(1) and using benzyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate (1.98 g), 1-cyclopropylmethanamine (570 mg) and lithium perchlorate (960 mg).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08575167B2uspto-grants-2013_11