Reaktion #2123274

Reaktionsgleichung

Benzyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate

cyclohexylamine

lithium perchlorate

→

product

Ausbeute 96.0%

benzyl 4-[(cyclohexylamino)methyl]-4-hydroxypiperidine-1-carboxylate

Ausbeute 96.0%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled to room temperature
2. 2
   SonstigeThe solvent was evaporated under reduced pressure
3. 3
   Sonstigethe residue was purified by silica gel column chromatography

Vorschrift

Benzyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate (1.98 g) was dissolved in acetonitrile (80 mL), and cyclohexylamine (800 mg) and lithium perchlorate (960 mg) were added. The mixture was stirred at 80° C. overnight, and cooled to room temperature. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography using basic silica gel (15% ethyl acetate/hexane to 80% ethyl acetate/hexane) to give the object product (2.39 g, 96%).

Quelle