Reaktion #2122488

Reaktionsgleichung

1-Methoxy-piperidin-4-ol

1-methoxy-piperidin-4-ol

triethylamine

Methanesulfonyl chloride

→

methanesulfonic acid 1-methoxy-piperidin-4-yl ester

Ausbeute 126.3%

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITat room temperature for an additional 1 hour
2. 2
   FiltrationThen the mixture was filtered
3. 3
   Sonstigethe solvent evaporated

Vorschrift

21 g 1-Methoxy-piperidin-4-ol (from Step 1) and 19.4 g triethylamine were dissolved in 200 ml ethyl acetate, and cooled to 0° C. 15.0 g Methanesulfonyl chloride was added slowly. The resulting white suspension was stirred at 0° C. for 1 hour, then at room temperature for an additional 1 hour. Then the mixture was filtered and the solvent evaporated, yielding 34.6 g of methanesulfonic acid 1-methoxy-piperidin-4-yl ester. This material was used for the next step without further purification.

Quelle