Reaktion #2121

Reaktionsgleichung

3-methyl-7-propyl-xanthine

diethyl 4-chlorobutanephosphonate

→

Diethyl [4-(3-methyl-7-propyl-xanthin-1-yl)butyl]phosphonate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigechromatographed on silica gel (eluent: dichloromethane/methanol 20:1)
2. 2
   Sonstigecrystallized from diisopropyl ether

Vorschrift

The title substance was prepared from 0.072 mol of 3-methyl-7-propyl-xanthine and 0.072 mol of diethyl 4-chlorobutanephosphonate analogously to Example 23, chromatographed on silica gel (eluent: dichloromethane/methanol 20:1) and crystallized from diisopropyl ether.

Quelle