Reaktion #2120

Reaktionsgleichung

7-methoxyethyl-3-methylxanthine

diethyl 4-chlorobutane-phosphonate

potassium carbonate

→

Diethyl [4-(7-methoxyethyl-3-methylxanthin-1-yl)butyl]phosphonate

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe solid was filtered off
2. 2
   Einengenthe filtrate was concentrated under reduced pressure
3. 3
   Filtrationfiltered again
4. 4
   Sonstigecrystallized from diisopropyl ether

Vorschrift

9 g (0.04 mol) of 7-methoxyethyl-3-methylxanthine were suspended in 100 ml of DMF, treated with 11 g (0.048 mol) of diethyl 4-chlorobutane-phosphonate and 10 g (0.064 mol) of activated potassium carbonate and heated at 70° C. for 4 hours. The solid was filtered off, the filtrate was concentrated under reduced pressure and the oily residue which remained was taken up in ethyl acetate, filtered again and crystallized from diisopropyl ether.

Quelle