Reaktion #2118

ord-bf99dda85e8446dfbb7ca469f46d02aa

Reaktionsgleichung

Cn1cnc2c1c(=O)[nH]c(=O)n2C
theobromine
CCOP(=O)(CCCCCl)OCC
diethyl 4-chlorobutanephosphonate
→
CCOP(=O)(CCCCn1c(=O)c2c(ncn2C)n(C)c1=O)OCC
Diethyl [4-(3,7-dimethylxanthin-1-yl)-butyl]phosphonate

Edukte

Cn1cnc2c1c(=O)[nH]c(=O)n2C
theobromine
CCOP(=O)(CCCCCl)OCC
diethyl 4-chlorobutanephosphonate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigecrystallized from diisopropyl ether

Vorschrift

The title substance was prepared from 0.075 mol of theobromine and 0.09 mol of diethyl 4-chlorobutanephosphonate analogously to Example 23 and crystallized from diisopropyl ether.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05728686uspto-grants-1998_03