Reaktion #2116

Reaktionsgleichung

benzylethyl 4-(7-ethoxymethyl-3-methylxanthin-1-yl)-butylphosphonate

ammonia

→

Monoethyl ammonium [4-(7-ethoxymethyl-3-methylxanthin-1-yl)butyl]-phosphonate

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe catalyst was filtered off
2. 2
   Einengenthe filtrate was concentrated under reduced pressure
3. 3
   Sonstigethe solution obtained
4. 4
   Sonstigeafter evaporating the solvent
5. 5
   Sonstigewas then crystallized from diisopropyl ether

Vorschrift

6.3 g (0.013 mol) of benzylethyl 4-(7-ethoxymethyl-3-methylxanthin-1-yl)-butylphosphonate were hydrogenated in 100 ml of ethanol over 0.5 g of palladium (10%) on active carbon at room temperature in the course of 4 hours. The catalyst was filtered off, the filtrate was concentrated under reduced pressure, the solution obtained was treated with methanolic ammonia and the residue which remained after evaporating the solvent was then crystallized from diisopropyl ether.

Quelle