Reaktion #2109

Reaktionsgleichung

diethyl 5-hydroxypentylphosphonate

3,4-dihydropyran

pyridinium toluene-4-sulfonate

→

Diethyl 5-(tetrahydropyran-2-yloxy)pentylphosphonate

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturunder reflux for 16 hours
2. 2
   WaschenThe solution was washed with water and saturated sodium hydrogen carbonate solution
3. 3
   Trocknendried over sodium sulfate
4. 4
   workup.DISTILLATIONdistilled in a bulb tube

Vorschrift

A solution of 66.9 g (0.298 mol) of diethyl 5-hydroxypentylphosphonate, 32.6 g (0.38 mol) of 3,4-dihydropyran and 1 g (0.004 mol) of pyridinium toluene-4-sulfonate in 800 ml of dichloromethane was heated under reflux for 16 hours. The solution was washed with water and saturated sodium hydrogen carbonate solution, dried over sodium sulfate and distilled in a bulb tube.

Quelle