Reaktion #2106

Reaktionsgleichung

diethyl 5-hydroxypentylphosphonate

4-toluenesulfonyl chloride

→

Diethyl 5-p-toluenesulfonyloxypentylphosphonate

Lösungsmittel

pyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONtreated
2. 2
   EinengenThe reaction mixture was concentrated under reduced pressure
3. 3
   Waschenwashed several times with 20% strength citric acid solution and water
4. 4
   Trocknendried over sodium sulfate
5. 5
   SonstigeAfter evaporating the solvent
6. 6
   Sonstigewhich was employed without further purification

Vorschrift

30 g (0.134 mol) of diethyl 5-hydroxypentylphosphonate (see Example 21) were dissolved in 200 ml of pyridine, and the solution was cooled to 0° C. and treated with stirring with 26.1 g (0.134 mol) of 4-toluenesulfonyl chloride. The reaction mixture was concentrated under reduced pressure, taken up in ethyl acetate, washed several times with 20% strength citric acid solution and water and dried over sodium sulfate. After evaporating the solvent, a pale yellow oil remained, which was employed without further purification.

Quelle