Reaktion #2105745

ord-7f3ca291d865490ab097b0844e39af0a

Reaktionsgleichung

Brc1ccccn1
Brc1ccccn1
Cn1cc(Nc2nc(O[C@H]3C[C@H](N(C)C(=O)OC(C)(C)C)C3)c3ccn(COCC[Si](C)(C)C)c3n2)cn1
Cn1cc(Nc2nc(O[C@H]3C
→
Cn1cc(N(c2ccccn2)c2nc(O[C@H]3C[C@H](N(C)C(=O)OC(C)(C)C)C3)c3ccn(COCC[Si](C)(C)C)c3n2)cn1
Cn1cc(N(c2ccccn2)c2n

Edukte

Brc1ccccn1
Brc1ccccn1
Cn1cc(Nc2nc(O[C@H]3C[C@H](N(C)C(=O)OC(C)(C)C)C3)c3ccn(COCC[Si](C)(C)C)c3n2)cn1
Cn1cc(Nc2nc(O[C@H]3C[C@H](N(C)

Reagenzien

CC(=O)[O][Pd][O]C(C)=O
Pd(OAc)2
c1ccc(-c2c3ccccc3cc3ccccc23)cc1
9-Phenylanthracene
C[Si](C)(C)[N-][Si](C)(C)C.[Li+]
LiHMDS
CC(C)(C)P(c1cc2ccccc2n1-c1ccccc1)C(C)(C)C
cataCXium PIntB

Lösungsmittel

Cc1ccccc1
Toluene

Reaktionsbedingungen

Temperatur
90°CELSIUS

Quelle

DOI: 10.1038/s4155739k HTE dataset from Pfizer