Reaktion #2101

ord-7fae1dd89d25493ea4ac31663986c9df

Reaktionsgleichung

COC(C)n1c(=O)c2[nH]cnc2n(C)c1=O
1-methoxyethyl-3-methylxanthine
CCOP(=O)(CCCCCl)OCC
diethyl 4-chlorobutanephosphonate
→
CCOP(=O)(CCCCn1cnc2c1c(=O)n(C(C)OC)c(=O)n2C)OCC
Diethyl [4-(1-methoxyethyl-3-methylxanthin-7-yl)butyl]phosphonate

Edukte

COC(C)n1c(=O)c2[nH]cnc2n(C)c1=O
1-methoxyethyl-3-methylxanthine
CCOP(=O)(CCCCCl)OCC
diethyl 4-chlorobutanephosphonate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigecrystallized from diisopropyl ether

Vorschrift

The title substance was prepared from 1-methoxyethyl-3-methylxanthine and diethyl 4-chlorobutanephosphonate analogously to Example 4 and crystallized from diisopropyl ether.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05728686uspto-grants-1998_03