Reaktion #2094

ord-8750cc7ad61a432da65104ddaeebb4b3

Reaktionsgleichung

CCOCn1c(=O)[nH]c2nc[nH]c2c1=O
1-ethoxymethylxanthine
O=C([O-])[O-].[K+].[K+]
potassium carbonate
CCCC(Cl)P(=O)(OCC)OCC
diethyl chlorobutanephosphonate
→
CCOCn1c(=O)c2c(ncn2CCCCP(=O)(OCC)OCC)n(C)c1=O
Diethyl [4-(1-ethoxymethyl-3-methylxanthin-7-yl)butyl]phosphonate

Edukte

CCOCn1c(=O)[nH]c2nc[nH]c2c1=O
1-ethoxymethylxanthine
O=C([O-])[O-].[K+].[K+]
potassium carbonate
CCCC(Cl)P(=O)(OCC)OCC
diethyl chlorobutanephosphonate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    FiltrationThe solution was filtered
  2. 2
    Einengenconcentrated
  3. 3
    Sonstigethe residue which remained was chromatographed (eluent: dichloromethane/methanol 20:1)

Vorschrift

4 g (0.018 mol) of 1-ethoxymethylxanthine were stirred at 70° C. for 6 hours with 3 g of potassium carbonate and 4.9 g (0.0214 mol) of diethyl chlorobutanephosphonate. The solution was filtered and concentrated, and the residue which remained was chromatographed (eluent: dichloromethane/methanol 20:1).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05728686uspto-grants-1998_03