Reaktion #2088

Reaktionsgleichung

7-ethoxymethyl-3-methylxanthine

ethyl iodide

potassium carbonate

→

7-Ethoxymethyl-1-ethyl-3-methylxanthine

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe solution was filtered
2. 2
   Sonstigethe residue which remained was crystallized in diisopropyl ether
3. 3
   Sonstige28.7 g (85% of theory) of the title substance were obtained
4. 4
   Sonstigeemployed without purification in Example 4b)

Vorschrift

30 g (0.134 mol) of 7-ethoxymethyl-3-methylxanthine were suspended in 500 ml of absolute DMF with 25 g (0.161 mol) of ethyl iodide and 22.2 g (0.161 mol) of potassium carbonate and the mixture was stirred at 70° C. for 5 hours. The solution was filtered and the residue which remained was crystallized in diisopropyl ether. 28.7 g (85% of theory) of the title substance were obtained and employed without purification in Example 4b).

Quelle